Dear SPM gurus, I was able to find in previous postings explanation of how to claculate the (mean brain normalized) percent change in a certain voxel (using plot -> contrast of parameter estimates), and how to obtain the time series of changes in a volume of interest (using the new spm_regions function). I was wondering if you could assist me with the following two questions: 1. How can one obtain the percent change estimate for a small V.O.I., i.e. a single number rather than the full time series? I'm getting too much variance when looking at the percent change in a single voxel, and I think that for instance, the mean beta values in a VOI would be a better representative. 2. Is there a simple way of finding the location of (global and/or local) maximal signal change, rather than the location where the t statistic is maximised? thanks in advance, Shy