While it is similar to that derived empirically by Zarahn and colleagues, I think the HRF used in SPM was actually derived by Karl Friston from a PCA across activated voxels (activation as determined by a Fourier set) from the data described in Josephs et al. (1997), but apologies to anyone concerned if my historical understanding is wrong. "Johnson, Sterling - MHA" wrote: > I believe the shape of the HRF was empirically derived based on the work of > Zarahn > > Zarahn, E., G. Aguirre, and M. D'Esposito, A trial-based experimental design > for fMRI. Neuroimage, 1997. 6(2): p. 122-38. > > Best wishes, > > Sterling C. Johnson, Ph.D. > Neuropsychology > Barrow Neurological Institute > 222 W. Thomas Rd. Ste 315 > Phoenix AZ 85013 > ph: 602-406-3671 > fx: 602-406-6115 > email [log in to unmask] > > > -----Original Message----- > > From: Dr Afraim Haddadi [mailto:[log in to unmask]] > > Sent: Wednesday, February 07, 2001 11:39 AM > > To: [log in to unmask] > > Subject: SPM HRF Reference > > > > > > Dear all, > > > > Can anyone provide me with a literature reference for > > the default canonical HRF shape, assumed by spm_hrf? > > > > Much appreciated, > > > > Afraim > > > > > > ---------- > > Dr A Salek-Haddadi > > Clinical Research Fellow > > Institute of Neurology > > -- ---------------------------8-{)}------------------------- DR R HENSON Institute of Cognitive Neuroscience & Wellcome Department of Cognitive Neurology 17 Queen Square London, WC1N 3AR England EMAIL: [log in to unmask] URL: http://www.fil.ion.ucl.ac.uk/~rhenson TEL1 +44 (0)20 7679 1131 TEL2 +44 (0)20 7833 7472 FAX +44 (0)20 7813 1420 --------------------------------------------------------- --