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Dear all. I'm reposting this question. There are 8 Abnormal and 6 control(Normal) subjects, and each 14 subject have PET scanned once at their baseline and activation status. I have done two SPM analysis to see deactivated regions even when they are in activated status such as... No.1. Abnormal group baseline and Abnormal group activation with contrast 1 -1 No.2. Normal group baseline and Abnormal group activation(same group as above) with contrast 1 -1 ... and there were results with deactivated regions on frontal lobe in the two analysis above, but No.2 had a smaller area than No.1 on frontal lobe. Then I assumed that Abnormal baseline would be in more activated status than Normal baseline status at least on frontal lobe. So I would like to validate the difference between Abnormal baseline and Normal baseline. I thought that it had to be seemed to have differences on frontal lobe as much as the difference between the result of No.1 and No.2. But the result isn't like that I have thought, and even almost no difference is appeared on frontal lobe. Would anyone please explain about this ?. Is this kind of analysis possible using SPM ?. Thanks in advance. Sincerely, Ha-Kyu Jeong