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Dear all, While we are on the subject, there is a good review on the physiology underlying PET (and fMRI) signal by: Jueptner, M. & Weiller, C. Review: does measurement of regional cerebral blood flow reflect synaptic activity? Implications for PET and fMRI Neuroimage (1995) 2;2:148-156. It concludes "...Monitoring of regional cerebral blood flow with PET or fMRI thus mainly reflects neuronal and more specifically (pre-) synaptic activity." The point that excitation and inhibition both lead to increases in signal is also well made; an area of potential confusion when people report 'deactivations'. Cheers. Alex.