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Dr. Talbot: This issue was discussed in detail in a recent paper: Shulman RG: Functional imaging studies: linking mind and basic neuroscience. Am J Psychiatry 2001 Jan;158(1):11-20. It can be accessed on-line at ajp.psychiatryonline.org. Good luck, Darin Dougherty, MD Massachusetts General Hospital > -----Original Message----- > From: Dr Peter Talbot [SMTP:[log in to unmask]] > Sent: Wednesday, March 28, 2001 1:06 PM > To: [log in to unmask] > Subject: Physiology underlying 'activations' > > Dear List > When someone undergos a particular cognitive activation task (eg a verbal > fluency test for sake of argument) and SPM finds 'activations' and > 'deactivations' relative to a control condition, what are the principle > contributors at the cellular and synaptic level to this increase or decrease > in > metabolic requirements in the region identified? > > For example, is it mainly the metabolic requirements related to > glutamate/other EAAs release and reuptake or are other identified > neurotransmitters equally or more important etc etc. Are the relevant > contributions of neuronal vs glial metablism known? > > And am I even right to assume that the 'activation' represents mainly synaptic > activity as opposed to, say, cell body metabolism? > > While the question is not completely SPM-related, I'd be grateful for any info > or to be pointed towards relevant references. > > Thanks in advance. > > Peter Talbot > ---------------------- > Dr Peter Talbot > Department of Mental Health > Queens University Belfast > Whitla Medical Building > Lisburn Road > Belfast BT9 7BL, > NORTHERN IRELAND, U.K. > > Phone: +44 (0)28 9027 2166 > Phone: +44 (0)28 9033 5791 > > Fax: +44 (0)28 9032 4543 > Email: [log in to unmask]