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Hi Federico, Thanks for the minimax ref. > Practically it does not give any different results from the usual > approaches but the theoretical aspects are interesting. In what context? In PET and FMRI datasets, comparing to FWE-corrected p-values (that is, p-values created in the usual way to control Familywise Type I error), I have found FDR to be considerably more powerful. (Were you referring to the minimax/wavelet-shrinkage problem?) I'm still getting a sense of how the power of (voxel-wise) FDR compares to the usual cluster size p-values, but it's hard to compare cluster- and voxel-wise inference. -Tom