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Dear All, Finally got my brain mask to work, however, the results are less than spectacular. I had hoped to increase sensitivity by applying the mask to EPI data, before using the GLM to estimate significance. However, when I look at the results only 0.6 resels are being sampled. This compares to 380 resels when I don't use a mask. I guess this is a side-effect of masking, which must be introducing "un-smoothness" into the dataset. Is this the correct interpretation? I have read that if one applies a mask at the SVC stage, the resel count is based on the smoothness of the whole head data. My questions are: 1.) is this a more/less valid approach than applying the mask to EPI data (as above)? and 2.) is there any way of obtaining an image of the SPM, when masking at the SVC stage? Any suggestions/comments greatly appreciated. Yours, Jon. _____________________________________________________ Jonathan Brooks Ph.D. (Research Fellow) Magnetic Resonance and Image Analysis Research Centre University of Liverpool, Pembroke Place, L69 3BX, UK tel: +44 151 794 5629 fax: +44 151 794 5635