 |
 |
Dear allstatters, I have been discussing schemes for a Phase 1 study to look at dose level and dosage form options for an anti-hypertensive therapy. My preference would be for a factorial design, looking a 3 factors at once, but my medical colleague was not convinced. In particular, he said that all the studies he had seen were of a simple parallel group design. He asked whether there were any precedents for using factorial designs in phase 1 for cardiovascular agents. I am well aware of the theoretical advantages of factorial designs and their practical utility in agricultural and industrial experiments. However, there seems to be a strong preference in clinical research for simple designs. Your mission, should you care to accept it will be to let me know if, in you experience, factorial designs are useful in Phase 1. Studies with cardiovascular agents would be of particular interest. I would also like to hear negative replies. Many thanks Tim Auton The views, opinions and judgements expressed in this message are solely those of the author. The message contents have not been reviewed or approved by Protherics. T R Auton PhD MSc C.Math Head of Biomedical Statistics Protherics Molecular Design Ltd Beechfield House Lyme Green Business Park Macclesfield Cheshire SK11 0JL UK email: [log in to unmask]