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Dear All, I would value opinions on an interesting case which presented to us last weekend. 13 month old boy H/O possible ingestion of few mouthfuls of methanol 2 hours earlier On admission: Na 137, K 4.2, Cl 105, HCO3 24, Urea 5.4, creatinine 367 umol/l(checked!) serum osmolality 289 glucose 4.8 No increased osmolal gap MLSO unhappy with creatinine and requested repeat sample (2 hours later) Na 136, K 4.7, HCO3 24, urea 5.5, creatinine 284 Paediatric registrar could not explain isolated rise in creatinine in presence of normal urea 12 hours later Creatinine 201, HCO3 25.8 12 hours later creatinine 165, HCO3 26.6 Child remained well throughout and was discharged home the following day. Our creatinines were measured using Olympus "O'Leary" modified Jaffe method. Initial creatinines (367 and 284 umol/l) rechecked using Vitros "enzymatic" dry chemistry method and measured 32 and 28 umol/l respectively!!!!. What could be causing the profound positive interference with the "O'Leary" modified method or is there another possible explanation? Peter Sharpe Consultant Chemical Pathologist Craigavon Area Hospital ##################################################################################### This e-mail message has been scanned for Viruses and Content and cleared by MailMarshal For more information please visit www.marshalsoftware.com ##################################################################################### Please note the information in this e-mail transmission may not be legally revealed and is intended only for the use of the individual(s) named above. If you are not the intended recipient you are hereby notified that any use, dissemination, distribution or copying of this e-mail message or its information is strictly prohibited. If you have received this e-mail in error please notify the sender by reply, and delete this message from your e-mail system(s). Whilst Craigavon Area Hospital Group Trust has taken every reasonable precaution to protect against infection by software viruses, we cannot accept liability for any damage which you sustain as a result of software viruses. You should therefore carry out your own virus checks prior to opening any attachment contained within this e-mail.