Throwing my hat into the ring, I very much agree with the sentiments expressed by Trish Greenhalgh, Andrew Booth and others regarding the need for a defensible methodology at NICE: There is surely NO justification for "confidentiality" when the appraisal of therapeutic efficacy should be conducted according to defensible criteria of validity and cost-benefit ratio AND be seen to be reproducible. Some "focused" questions that perhaps need some answers for the list's benefit are: 1. Does NICE have agreed standards and documentation for their appraisal process? 2. Is it possible to obtain details of these methods (cp CRD Report 4, Cochrane Handbook)? 3. Are these methods methodologically rigorous? I am sure that I was one of many who requested that NICE should make their methodology and review processes transparent and accessible when I responded to their public consultation paper on 'developing clinical guidelines' at the end of March this year. Alison Dr Alison Weightman Information Resources Manager Health Evidence Bulletins - Wales Duthie Library University of Wales College of Medicine, Cardiff, CF14 4XN. UK e-mail: [log in to unmask] Telephone: 02920 745142 Fax: 02920 742574 Web site: http://hebw.uwcm.ac.uk http://www.uwcm.ac.uk/uwcm/lb/pep %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%