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Dear Giandomenico, > BOLD acquisition > voxel size (mm): 3.75x3.75x4 > Dimension: 64x64x25 > Origin:32x32x13 > > T1 acquisition > voxel size (mm): 0.94x0.94x3.30 > Dimension: 256x256x25 > Origin: 0x0x0 I would try changing the header of the T1 image to the same anatomical location as the origin of the BOLD images, before doing coregistration. At the moment it looks as if there is not be enough overlap in the images. Best wishes, Geraint -- Dr. Geraint Rees Wellcome Advanced Fellow, Lecturer, Division of Biology 139-74, Institute of Neurology, California Institute of Technology, University College London, Pasadena CA 91125 London WC1N 3BG voice 626-395-2880 020-7833-7472 fax 626-796-8876 020-7813-1420 web http://www.klab.caltech.edu/~geraint -- %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%