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Dear Dr. Symms, > I have 160 FMRI volumes of varying contrast that I would like to > realign. Is it possible to use the Mutual Information cost function in > the Realignment routine ? The way the defaults are set out seems to > imply that MI is only available for Coregistration. Coregistration is the same as realignment, so the answer is yes. The warning "only for coregistration" is that you cannot use MI to normalise images. Cheers, Alle Meije -- Alle Meije Wink Institute for Mathematics and Computing Science, room 105 University of Groningen P.O. Box 800 9700 AV Groningen Telephone +31 50 363 71 27 The Netherlands Fax: +31 20 875 48 00 E-mail: [log in to unmask] WWW: http://www.cs.rug.nl/~wink " I guess it comes down to a simple choice, really. Get busy living, or get busy dying. " (Andy Dufresne in The Shawshank Redemption) %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%