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Dear Daniel, There's nothing obviously wrong with the model parameters you entered. If I'm right, your study contains 74 sessions of 176 scans each i.e. 13024 scans which is a very large analysis - your computer could be running out of steam and/or swap space for the MATLAB process! Do you have any information on the machine you are using? You don't mention whether any errors appeared in the MATLAB window when the progress bar was stuck; these will give some clues as to what is going wrong (e.g. is there a MATLAB 'Out of Memory' error? ). I'm afraid there's no easy way to edit the SPM_fMRIDesMtx.mat (other than by directly modifying the variables in MATLAB). But I think the root of the problem may be with the overall size of the analysis. One way round this would be to move to a second level analysis after a first level analysis within-subjects. best wishes, Geraint ----------------------------------------------------------------- Dr. Geraint Rees Wellcome Advanced Fellow Lecturer California Institute of Technology Institute of Neurology Division of Biology 139-74 University College London Pasadena 12 Queen Square California 91125 London WC1N 3BG voice (626) 395-2880 voice (171) 833-7472 fax (626) 796-8876 fax (171) 813-1420 http://www.klab.caltech.edu/~geraint [log in to unmask] ----------------------------------------------------------------- %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%