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At 11:24 AM 3/20/00 -0500, Stephan Hamann wrote: >We're preparing to conduct a study of the effect of a drug on memory >function and hippocampal activity, using O-15 PET. PET was originally >chosen partly because we wanted to hook up a lot of equipment that would >not be feasible in an fMRI environment. Now, however, I'm considering a >streamlined version that could work nicely in the magnet. My question is, >I have so far seen very few drug studies with fMRI(as compared to PET). Is >there any intrinsic reason why fMRI is less suited to drug effects >studies? I haven't been able to find any references to this topic and >would very much appreciate some pointers. I realize that for fMRI one >would need to treat the drug effect as an interaction effect (i.e., how >does the drug treatment affect the difference between the activation >memory task and a reference control task?), but are there any >considerations beyond that? > >Stephan Hamann >Dept. of Psychology >Emory University >Atlanta, GA 30322 >[log in to unmask] > > > > >Dear Steve, There are a number of references on psychopharmacology and fmri. The two main groups that have been working on this are Elliott Stein's lab in Milwaukee and the MGH group, although I believe a number of labs are working on ph-fMRI now. Here is a list of some useful refs: (a) FMRI in pharmacology. EA Stein et al. In Moonen CTW and Beandettini (eds) Functional MRI. Springer, 2000. (b) Chen YCI et al. Detection of dopaminergic neurotransmitter activity using pharmacological MRI. MRM 38, 389-98 (1997) (c) Chen YI et al. Detection of dopaminergic cell loss and neural transplantation using ph-fmri, pet, and behavioural assessment. Neuroreport 1999; 10: 2881-6 (d) Vaidya CJ et al. Selective effects of methylphenidate in adhd:a fmri study. PNAS 95, 14494-9, 1998 (e) Breiter HC et al. Acute effects of cocaine on human brain activity and emotion. Neuron 19, 591-611, 1997 (f) Stein EA et al. Nicotine induced limbic cortical activation in the human brain. Am J Psychiatry 1998; 155: 1009-15 (g) Chen Q et al. fMRI of basal ganglia responsiveness to l-dopa in parkinsonian rhesus monkeys. Exp Neurol 1999; 158: 63-75 (h) Marota JJA et al. Cocaine administration discriminates dopaminergic projections by temporal response. Neuroimage 11, 13-23, 2000 (i) Bloom A et al. Determination of drug-induced changes in fmri signal using a pharmacokinetic model. Hum Brain Mapp 1999; 8: 235-44 (j) Li S-J et al. Cocain administration decreases functional connectivity in human primary visual and motor cortex as detected by fMRI. MRM 2000; 43: 45-51. (k) Sell LA et al. fMRI imaging of the acute effects of iv heroin administration on visual activation in long-term heroin addicts. Drug Alcohol Depend 1997; 49: 55-60 (l) Gollub RL et al. Cocaine decreases cortical cerebral blood flow but does not obscure regional activation in fMRI in human subjects. JCBFM 1998; 18: 724-34 The Stein review chapter is a good place to read about possible probems with ph-FMRI including head movement, effects on physiological noise, drug effect on cerebral cortical microcirculation, etc. Happy reading!! Best wishes, Andrew __________________________________________ Andrew Lawrence PhD, MRC Cognition and Brain Sciences Unit, 15 Chaucer Rd, Cambridge CB2 2EF, UK http://www.mrc-cbu.cam.ac.uk/~andrew.lawrence/ %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%