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I am trying to determine the proper threshold to exclude non-gray matter voxels from the analysis. It seems that the default 0.8 threshold may be too liberal and may be including too many white matter voxels, in turn inflating the search volume and decreasing the statistical power. On the other hand, I don't want to make the threshold too stringent and exclude critical areas that have relatively low counts (e.g., amygdala). Is it correct that I could use the Check Registration function to compare a voxel in a specific subject's image with the mask.img that is created during the analysis to confirm whether that voxel in a particular region was included or excluded from the analysis ? sg ( Note new e-mail address: [log in to unmask] ) ==================================== Steven Grant, Ph.D. Cognitive Neuroscience of Addiction Program Clinical Neurobiology Unit Div. Treatment Research & Development National Institute on Drug Abuse Room 4-4238 6001 Executive Blvd Bethesda, MD 20892 301 443-4877 (voice) 443-6814 (fax) %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%