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An established measure is the Likelihood Ratio (LR). You may use the LR+ and LR- for each cutoff point, or you can use multilevel likelihood ratio which is the LR for each outcome of the test. The latter is not so much used. Centor RM. Estimating confidence intervals of likelihood ratios. Med Decis Making 1992;12:229-33. Regards Roland Andersson, MD PhD Department of Surgery County Hospital Ryhov S-551 85 Jönköping SWEDEN e-mail: [log in to unmask] phone: +46-36-321344 fax: +46-36-321321 ____________________________________________ //\\//\\//\\//\\//\\//\\//\\//\\//\\//\\//\\ David manton wtote: I am familiar with traditional diagnostic indices (e.g. sensitivity and specificity) for quantifying the efficacy of a particular test when the diagnosis is based around TWO categories/groups (e.g. benign versus malignant tumours). My question is, are there any similar, established methods/indices for quantifying diagnostic efficacy when there are MULTIPLE categories/groups (e.g. malignant tumours, totally benign tumours and benign tumours regarded clinically as having an increased chance of progressing into malignant disease because of co-existant pathology)? David Manton, Ph.D. (Medical Physics) YCR Centre for MR Investigations, Hull Royal Infirmary, Anlaby Road, Hull, UK. HU3 2JZ mailto:[log in to unmask] ---------------------------------------------------- %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%