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Dear All, Can anyone provide me with any references that give details of how to determine sample sizes required for studies looking at the repeatability and agreement of different methods of measurement. I have found several very good references that give information on how to analyse such studies, but none of them appear to indicate how to determine sample sizes required. Many thanks, Emma Salmon ---------------------- Statistician Clinical Trials & Statistics Unit Section of Epidemiology Institute of Cancer Research Block D 15 Cotswold Road Sutton Surrey SM2 5NG Tel. 020 8722 4013 Email: [log in to unmask]