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> ******* UCL STATISTICS SEMINAR **************** > > All are welcome > > Please see our web page for details of further seminars and how to find > us: www.ucl.ac.uk/stats/research/journals.html > Monday 30th October 2000 - 4pm, Room 102, 1-19 Torrington Place, > Department of Statistical Science - University College London. > Speaker: Bob Griffiths, Oxford Ancestral Inference from Stochastic Gene Trees A unique gene tree describing the mutation history of a sample of DNA sequences can be can be constructed as a perfect phylogeny under an assumption of non-recurrent point mutations. The tree is equivalent to the DNA sequence data and because of ancestry there is much interest in thinking of the DNA sequence data as a tree. The likelihood of a gene tree under a stochastic coalescent model of evolution can be found by an advanced simulation technique, thus allowing maximum likelihood estimation of parameters using the full information in the data. The distribution of the time to the most recent common ancestor and ages of mutations in the gene tree, conditional on its topology, can also be found by the simulation technique. Dr Andrew Copas Lecturer in Medical Statistics Departments of Statistical Science & Sexually Transmitted Diseases University College London [log in to unmask] & [log in to unmask] %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%