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MATHSOFT INTERNATIONAL S-PLUS TRAINING COURSES JUNE 2000 Design, Monitoring and Analysis of Group Sequential Clinical Trials wih Scott Emerson and John Kittleson June 13-14 Royal Society of Medicine, London, UK June 20-21 Basel, Switzerland June 26-27 Paris, France June 29-30 Heidelberg, Germany Course Description Increasingly, clinical trials are conducted using group sequential methods in order to address the ethical and efficiency issues that arise when performing experiments with human volunteers. The design, conduct, and analysis of a sequential clinical trial is necessarily more involved than that for a clinical trial in which the data would only be analyzed at the end of the study. In this short course we present the additional issues that must be considered when conducting a group sequential trial. The group sequential methods are illustrated using S+SeqTrial , a module for the design, monitoring, and analysis of clinical trials. Course participants will receive hands-on instruction in the use of S+SeqTrial to perform the various statistical tasks necessary from start to finish in the conduct of a clinical trial. For further information and to register, please see our web page: http://www.mathsoft.co.uk/splus/main/courses.htm Anita Sharma MathSoft International Knightway House, Park Street Bagshot, Surrey GU19 5AQ tel: +44 (0)1276 450120 fax: +44 (0)1276 451224 email: [log in to unmask] %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%