A haematology colleague had an almost identical case as you describe here.
There are known associations between high ferritin levels and malignancy,
particularly renal cell carcinoma ("Serum Ferritin as a clinical marker for
renal cell carcinoma", Urol Int 1999;62(1):21-5). In our patient further
investigation revealed she had a large renal cell carcinoma.
> -----Original Message-----
> From: Huw Griffiths [SMTP:[log in to unmask]]
> Sent: 28 November 2000 18:06
> To: [log in to unmask]
> Subject: L/H-type Ferritin
>
> One of our physicians has been investigating a 51-year old woman
> for possible iron overload. Serum Ferritin 2025 mcg/L (15-233). However,
> serum Fe/TIBC normal, LFTs normal, Liver biopsy & genetic studies
> not consistent with haemochromatosis. He has asked if L and H-type
> serum ferritin concentrations can be measured. He is considering
> an autosomal dominant condition in which hyperferritinaemia is associated
> with cataract formation, in which ferritin is composed mostly of
> the L-type subunits. Can anyone help/advise on the determination
> of ferritin H/L subunits?
> Thanks
> --
> Huw Griffiths
> Huddersfield Royal Infirmary UK
>
>
>
>
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