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I note both CK tests are reported in units. The activity based assay for CKMB works by inhibiting the CK-M subunit, measuring B and then multiplying by 2 to get a CKMB activity. Therefore if you have a lot of CK-BB, you get wierd results - This sample could be the results of having 725 UNits of the total CK activity due to BB subunit ? a brain injury??? TIM *************************************************************************************** Prof. T. Reynolds, Clinical Chemistry Dept, Queens Hospital, Belvedere Rd., Burton-on-Trent, STAFFS, DE13 0RB. --------- Tel: +44 (0)1283 511511 ext. 4035 Fax: +44 (0)1283 593064 ----------- [log in to unmask] -----Original Message----- From: c=GB;a=NHS;p=NHS NATIONAL INT;dda:RFC-822=acb-clin-chem-gen-request(a)mailbase.ac.uk; Sent: Thursday, October 26, 2000 2:37 PM To: c=GB;a=NHS;p=NHS NATIONAL INT;dda:RFC-822=acb-clin-chem-gen(a)mailbase.ac.uk; Subject: CKMB problem A recent request for CKMB revealed a total CK of 778 IU/L and a CKMB of 1449 IU/L (both were measured using Roche reagents). Other tests and controls in the batch did not reveal any such anomalies. I have a vague recollection of this sort of effect possibly being caused by binding of the enzyme to an immunoglobulin. Any other ideas? Dr D G Williams FRCPath ---------------------------------------------------------- This message was sent using http://uk2.net NEWS - CHEAPEST DEDICATED SERVERS IN THE WORLD - 29/month UK's FREE Domains, FREE Dialup, FREE Webdesign, FREE email %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%