 |
 |
For what it's worth, I'm with Eric (and Gil) on this one. Even though his spelling is abysmal. ************************************* Dr RDG Neely Department of Clinical Biochemistry North Durham Healthcare NHS Trust Dryburn Hospital Durham DH1 5TW Tel. 0191 3332440 Fax. 0191 3332679 ************************************* -----Original Message----- From: Eric Kilpatrick [mailto:[log in to unmask]] Sent: 04 October 2000 07:23 To: Sharpe, Peter Dr Cc: ACB Mailbase Subject: Re: statins & fibrates in children This was debated at the recent British Hyperlipidaemia Association meeting in Nottingham. A paediatrician spoke of how he gave statins to his familial hypercholesterolaemic child patients with little apparent ill effect. Respected elder statesmen like Gil Thompson argued there was no evidence that delaying lipid lowering treatment until adulthood in these patients was detrimental to their survival. The BHA guidance lies somewhere in the middle. I must admit, I tend to agree with the Gil Thompson argument, simply because we do not know the effect that reducing intracellular cholesterol (remember, it affects all cells) may have on growing people. After all, we would be struck off if we knowingly gave the drugs to a pregnant women who, when you think about it, is simply carrying a very young growing person. Luckly, as you know, absolute hypercholesterolaemia does not seem to be a terrible problem until after puberty. I prefer to give resins (which are not absorbed systemically) if I am going to give anything although compliance is abismal. I think even less is known about the effects of fibrates although fenofibrate is one of the few lipid lowering drugs with a license for children. Unless Peter Galloway knows better, I suspect the likes of type 3 hyperlipidaemia seldom manifests until adulthood. Dr. Eric S. Kilpatrick Consultant in Chemical Pathology Hull Royal Infirmary Anlaby Rd Hull HU3 2JZ Tel: 01482-607708/607743 ----- Original Message ----- From: Sharpe, Peter Dr <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, October 04, 2000 2:57 PM Subject: statins & fibrates in children > Does anyone have extensive experience or advice on the use of statins & > fibrates in children and teenagers who are at very high risk of developing > coronary heart disease? > > Peter Sharpe > %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%