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In message <[log in to unmask]>, Chan, Dr. Konrad <[log in to unmask]> writes >Does anyone have any experience in applying Troponin-I levels for the >administration of anti-Gp IIb/IIIa (or anti-platelet) agent in acute >coronary syndrome? We are implementing Dade Stratus CS for TnI measurement. > >Ideally I think we should establish our own TnI reference range for the >diagnosis of acute coronary syndrome because the TnI assays are not >universally standardized. However, I understand that manufacturers do >provide limited data from clinical trials on their specific assay for the >establishment of their reference interval for diagnosis of acute coronary >syndrome. We users can adopt this set of figures provided we verify this >with a small-scale study of our own. > >My question is: to what extent do other users go in this verification >process? I understand that to absolutely exclude acute myocardial >infarction, which means we need to go beyond ECG and laboratory diagnoses - >ie require echocardiogram, radionucleotide scans and coronary angiograms, >tests which have higher specificity in diagnoisis of AMI. In my opinion this >is out of our ability in a small community hospital. > >Thank you for your input. > There is data from PRISM and CAPTURE for T and I (but Axsym). The Stratus is probably OK but there is no direct published data, only inferentiaol at this point -- Paul Collinson %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%