AMJ Paans wrote:
> Dear SPM'ers
> We are prepairing a PET rCBF experiment where in one of the
> conditions the p(CO2) can/will be changing. This will influence
> the gCBF because 1mm Hg in p(CO2) causes 6% difference in gCBF.
> We have possibilities to keep the p(CO2) in hand but into what
> extent we have to do this, because the possibilities are limited, for
> an analysis with SPM we do not know. Has anyone looked into
> this problem??
The best solution scientifically is to measure absolute blood flow with
arterial sampling. Then absolute global CBF can be entered as the
covariate at the normalization step. Of course practically this is more
challenging.
K Black MD
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