> Subject: from Ciprian Enachescu
> >Please tell me the more exactly definition for radiosensitivity.
I think it is safest to restrict definitions of radiosensitivity to the cell
survival curve, preferably determined by clonogenic assay, and not to DNA breaks
or other phenomena. Commonly used parameters to compare cell lines are SF2
(surviving fraction at 2Gy, dose chosen because it the most commonly used
individual fraction dose in radiotherapy), D10 (dose required to give a
surviving fraction of 10%), alpha/beta ratio and absolute values of alpha beta
(coefficients of the linear-quadratic fit to the survival curve), and D bar
(area under the survival curve, linear SF vs dose.)
Adrian Begg
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