The evening prior to the RSS/Biometric Society meeting on
Analysis of Genetic Data the General Applications Section will be holding
a related meeting which may be of interest to those planning to attend the one
day meeting.
Mike Denham
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Details follow:
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RSS - GENERAL APPLICATIONS SECTION
Monday 22 March, 4:00pm at the RSS (Tea 4:45pm)
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4:00pm PAK SHAM (Institute of Psychiatry)
Mapping QTL by linkage and association: models, power, and selection strategies
A variance-components model for QTL linkage and association analysis will be
presented. Approximate expressions for the powers of the two tests will be
derived. Procedures for optimal sample selection based on trait scores will be
described.
5:15pm JOHN WHITTAKER (University of Reading)
Allelic association in complex diseases
There has been much recent interest in the possibility of using allelic
association to locate the genes contributing to complex human diseases. Data
are often assumed to consist of genotypic information on family units comprising
an affected individual and both parents of that individual. We review briefly
the key concepts involved in the analysis of such data, and point out some
connections between the many methods of analysis that have been suggested. The
reliability in finite samples of the asymptotic distributional results that are
usually relied on will be assessed. We will discuss the value of data on
unaffected siblings of affected individuals, either in addition to the affected
individual-parent trios described earlier, or in cases where parental
information is unavailable. The possible advantages of enriching samples with
families where one or more parents are also affected will be considered.
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