...Reminder
...Apologies for late and X posting
CENTRE FOR MEDICAL STATISTICS
SEMINAR SERIES on BIOSTATISTICS 1998/99
NO 10: Wednesday, June 2nd, 1999 4:30pm
by
Dr Bob Griffiths
(University of Oxford)
Variation in DNA sequences is being used to infer human ancestry;
the tools to do this are stochastic models of evolution and statistical
analysis of the data using computationally intensive methods.
DNA sequences in a sample are not independent data, but are related
through an ancestral tree. Mutations along lines in the ancestral tree
produce variation at DNA sites in the sequences. The stochastic
model of ancestry is a coalescent process with mutations occurring
according to a Poisson process along the edges of the tree. An
advanced simualtion techique loosely related to Markov chain Monte
Carlo simulation produces simulated likelihood curves for the mutation
rate. Once this rate is estimated then the distribution of the time to
the ancestor of the sample sequences and ages of mutations can
be found, conditional on the pattern of mutations observed.
All welcome !!
Room 2.22
The MacKay Building
Keele University
Campus Map
http://www.keele.ac.uk/university/campus/maps/campus.htm
Best
Gilbert
_____________________________
Prof. Gilbert MacKenzie
Director,
Centre for Medical Statistics
Keele University
Staffordshire ST5 5BG
England
Tel: (01782) 583651
Fax: (01782) 584268
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