DEPARTMENT OF MEDICAL STATISTICS
DE MONTFORT UNIVERSITY, LEICESTER
Seminar Announcement
Time: Wednesday, 27th October 1999, 2 p.m.
Place: James Went Building, DMU Leicester
Room JW 6-18
Speaker: Dr. Steve Coad
University of Sussex
Title: A COMPARISON OF THE RANDOMISED PLAY-THE-WINNER RULE AND THE
TRIANGULAR TEST FOR CLINICAL TRIALS WITH BINARY RESPONSES
Abstract
A clinical trial model is considered in which an experimental treatment
is compared with a control treatment and the responses are binary. For
a fixed significance level and power, two designs are compared - the
randomisedplay-the-winner rule and the triangular test. The former is
an example of an adaptive design while the latter is an example of a
fully sequential design. It is shown how the sample size may be
determined for the randomised play-the-winner rule and how the stopping
boundaries may be chosen for the triangular test so that the two designs
have similar power functions. With this choice of design parameters,
simulation indicates that the triangular test is generally more
effective at reducing the expected number of treatment failures,
particularly when there is a large difference between the two
probabilities of success. The expected number of treatment failures can
be further reduced if the triangular test is applied using the
randomised play-the-winner rule to assign each patient to one of the two
treatments. (The talk is based on a joint paper with Bill Rosenberger
that appeared in Vol. 18, pp.761-769, of Statistics in Medicine in
1999.)
Info: J. S. Denne, [log in to unmask], tel. (0116) 2551 551 x 8509.
------------------------------------------------------------------
Jon Denne PhD, Dept of Medical Statistics, De Montfort University,
The Gateway, Leicester LE1 9BH, United Kingdom.
Email: [log in to unmask]
Tel: +44 116 2551551 ext 8509 Fax: +44 116 2471967
------------------------------------------------------------------
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|