In message <[log in to unmask]>, McNeely, Michael
<[log in to unmask]> writes
>We have a local "dispute" regarding the reporting of serum protein
>electrophoretic patterns in which a monoclonal gammopathy has appeared.
>
>Both "camps" believe that reporting a quantitation of the monoclonal band is
>appropriate.
>
>However, the difference lies in how the rest of the gamma globulin region should
>be reported.
>
>1. One camp feels that the "gamma globulin" should be all the gamma globulin
>(the sum of the monoclonal plus all the "normal" gamma globulin).
>2. The other camp wishes to report the monoclonal and then "all the rest" of the
>gamma globulin as a separate amount (total gamma minus the monoclonal).
>
>The arguement for option 2 is that it provides a better indication of
>hypogammaglobulinemia or "nromal" gamma proteins. The counter arguement is that
>the monoclonal measurement includes a portion of the "normal" gamma globulin
>within it.
>
>Is there a guideline covering this?
>
>Michael McNeely MD FRCPC
>
>
I don't knoew if there is a guideline: we use option 2.
TIM
--
Prof. Tim Reynolds,
Professor of Chemical Pathology,
Queen's Hospital,
Burton-on-Trent,
UK.
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