Dear John,
The original Cockcroft and Gaault formuala (Nepron 1976 Vol 16 31-41)
as you can see has been around for a number of years, and it has been
taekn as read that the final answer is in ml/min. This has been
reevaluated many times (eg Smith et al, DICP Ann Pharmacother 1990 25
169-177) and as I have mentioned before it has been used in therapeutic
drug monitoring for many years. Why use ml/min. One reason is that
creatinine clearance gives us an idea of how some drugs are cleared and
SI units or no, drug clearance is measured in ml/min or l/h.
Graham Mould
--
Dr Graham Mould
Guildford Clinical Pharmacology Unit
Royal Surrey County Hospital
Guildford, Surrey, UK
Tel 00 44 1483 (0) 406886
Fax 00 44 1483 (0) 455375
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