I am currently looking into Interim Analysis techniques and have come across
the paper by O'Brien and Fleming "A Multiple Testing Procedure for Clinical
Trials" Biometrics 35 pg. 549-556 September 1979. This proves to be quite
heavy going and I am not sure how to obtain Significance levels for my
interim analyses from the data in the paper.
I would like to know if anyone on allstat knows of any other
papers/books/literature on this subject or how to interpret the paper by
O'Brien and Fleming.
Many thanks
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