PSI TRAINING COURSE
SAMPLE SIZE AND POWER
Date 2nd and 3rd December 1999
Time 11.00 to 17.30 on Day 1 (registration from 10.30)
09.00 to 16.30 on Day 2
Location The Linton Lodge, Oxford
Course Fee PSI Members £468.09 (plus £81.91 VAT @ 17.5%)
Non Members £489.36 (plus £85.64 VAT @ 17.5%)
This course is aimed to cover the art as well as the science of sample size estimation, particularly in clinical trials. The basic concepts of effect size and power will be covered and the applications to parallel group and matched or cross-over studies will be discussed. The different requirement for bioequivalence studies will also be addressed. Applications will be considered in survival analysis, logistic regression and quality of life data. A generally robust view will be adopted, and practice given in eliciting effect sizes and sensitivity analyses encouraged.
The course will be presented by:
Mike Campbell, Professor of Medical Statistics, Institute of Primary Care, University of Sheffield
and
David Machin, Professor of Clinical Trials Research, Clinical Trials and Epidemiology Research Centre, Singapore
The course registration fee includes morning coffee, lunch, afternoon tea, dinner and overnight accommodation (with en-suite facilities) on 2nd December plus breakfast, morning coffee, lunch and afternoon tea on 3rd December.
Places are limited and can only be reserved on receipt of a completed registration form which may be obtained from:
PSI Executive Office, Resources for Business, South Park Road, MACCLESFIELD, Cheshire, SK11 6SH
Telephone +44 (0)1625 511750 Facsimile +44 (0)1625 267879
to whom completed forms should also be returned.
A confirmation letter, invoice and hotel details will be sent to each delegate on receipt of the completed registration form. Payment should follow by post as soon as possible.
Sample Size and Power: Course Content
SESSION 1
Basics:
why sample size calculations?
sample size for simple two group studies
SESSION 2
Sample size for:
two means, paired data and repeated measures data
two proportions, paired data
SESSION 3
Sample size for:
equivalence and bioequivalence studies
confidence intervals
non-parametric analyses and ordered categorical data
logistic regression
SESSION 4
Sample size for failure time data
Timing of analyses
Effect of dropouts
SESSION 5
Sample size for:
more than 2 groups
phase IV studies
cluster randomised trials
SESSION 6
Sample sizes for quality of life measures
The course will include practical sessions and demonstrations of sample size packages.
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