DEPARTMENT OF MEDICAL STATISTICS
DE MONTFORT UNIVERSITY, LEICESTER
Seminar Announcement
Time: Friday, 19th November 1999, 1 p.m.
Place: James Went Building, DMU Leicester
Room JW 6-18
Speaker: Anthony C. Atkinson
The London School of Economics, London WC2A 2AE, UK
Title: The Comparison of Designs for Sequential Clinical Trials
with Covariate Information
Abstract
The paper develops methods for the comparison of randomized rules of the
biased-coin type for the sequential allocation of treatments in a
clinical trial. One important characteristic is the loss, which measures
the increase in the variance of parameter
estimates due to the imbalance caused by randomisation. The other
important characteristic is the selection bias measuring the probability
of correctly guessing which treatment is to be allocated next. The
combination of these two measures leads to the elucidation of admissible
designs. Simulations provide clear plots of the behaviour of the designs
and make it possible to istinguish good designs from those which are
less good.
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A.N. Donev, Dept of Medical Statistics, De Montfort University,
The Gateway, Leicester LE1 9BH, United Kingdom.
Email: [log in to unmask]
Tel: +44 116 2506327 Fax: +44 116 2471967
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