J Assoc Acad Minor Phys 1998;9(1):9-15
Improved social and language skills after secretin administration in
patients with autistic spectrum disorders.
Horvath K, Stefanatos G, Sokolski KN, Wachtel R, Nabors L, Tildon JT
Department of Pediatrics, University of Maryland School of Medicine,
Maryland, USA.
We report three children with autistic spectrum disorders who underwent
upper gastrointestinal endoscopy and intravenous administration of secretin
to stimulate pancreaticobiliary secretion. All three had an increased
pancreaticobiliary secretory response when compared with nonautistic
patients (7.5 to 10 mL/min versus 1 to 2 mL/min). Within 5 weeks of the
secretin infusion, a significant amelioration of the children's
gastrointestinal symptoms was observed, as was a dramatic improvement in
their behavior, manifested by improved eye contact, alertness, and expansion
of expressive language. These clinical observations suggest an association
between gastrointestinal and brain function in patients with autistic
behavior.
PMID: 9585670, UI: 98246761
Here is a recent paper (the only one available) on secretin and its use in
autism. I think secretin used to be known as somatostatin. Hope this is
useful!
CK Khong
Warrington PCAPS
> ----------
> From: Doug Jenkinson[SMTP:[log in to unmask]]
> Reply To: [log in to unmask]
> Sent: 25 November 1998 10:40
> To: GP-UK Mailing list
> Subject: secretin
>
> >A friend emailed me:
>
> >I was going to contact you over the weekend anyway and ask your advice. A
> >good friend of mine has an autistic son and recently went to the States
> for
> >treatment. This was an injection of "secretin" which I understand is
> >manufactured by a Swedish company called Ferrin. Apparently he requires
> an
> >injection once a month and obviously cannot keep going to the states for
> >this. We may be able to obtain the drug but would then need someone to
> >administer it. Are you aware of this drug or know anything about this
> >subject.
>
> >Anyone heard about it?
>
> Some very intelligent patients of mine with an autistic child have
> persuaded
> me to refer them privately to a paediatric neurologist for the
> consideration
> of secretin treatment. Its serendipitously revealed effects on autism are
> anecdotal but compelling at first sight. He is sympathetic and is
> considering it.
>
> Doug Jenkinson
>
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|