Ann Neurol 1994 May;35(5):530-533
Zoster sine herpete, a clinical variant.
Gilden DH, Wright RR, Schneck SA, Gwaltney JM Jr, Mahalingam R
University of Colorado School of Medicine, Department of Neurology, Denver
80262.
Two otherwise healthy immunocompetent men, ages 62 and 66 years, experienced
years of radicular pain without zoster rash. An extensive search for
systemic disease and malignancy was negative. Varicella-zoster virus DNA,
but not herpes simplex virus DNA, was found in the cerebrospinal fluid of
the first patient 5 months after the onset of pain, and in the second
patient 8 months after the onset of pain. Prolonged radicular pain without
zoster rash combined with the presence of varicella-zoster virus in the
cerebrospinal fluid indicates that both men had zoster sine herpete, and
strongly supports this syndrome as a clinical variant.
Dr Jon Wilcox
General Medicine, Paediatrics and Obstetrics,
Glenfield Medical Centre,
452 Glenfield Road,
Auckland 1310, New Zealand
Phone or Fax +649-444-7656
e-mail [log in to unmask]
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