At 01:34 AM 1/14/98 -0000, Adrian Midgley wrote:
>[log in to unmask],Net wrote at 23:12 on 13/01/98
>about "Re: Nifedipine ?link with Stroke /Ca":
>-----------------------------
>>abayomi.mcewen wrote:
>>> Patient had seen TV programme which patient said linked use of
>>> Nifedipine with stroke and/or cancer. Did any of you see it? What did
>>> it really really say?
>>> (...)
>
>The suggestion was that there had been an increased
>incidence of cancers in Nifedipine users.
>
>The putative mechanism was that calcium channel blockade
>might inhibit the programmed autodestruction which cells
>demonstrate and which is thought to be one of the
>protections against multiplication of a cell which has
>turned cancerous. Apoptosis is it?
>this hypothesis is a bit difficult to credit. the assumption that the
l-channel regulate calcium leels in cell types that precipitate the
apparent increase in malignancy is invalid. basically, the channel is
present on excitable cells like muscles/nerves, where malignancy is rare.
ironic that hypertension itself is a significant risk factor for cancer.
>Tenous, very tenous, but no doubt the Apricot fancying
>godfreaks will believe it.
>--- OffRoad 1.9r registered to Adrian Midgley
>
>
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|