>There is no trial evidence that doses of 10mg of simvastatin decreases
>risk.All the trials used 20mg plus doses
Not so. 4S titrated dose v effect with targets either cholesterol <5.2 OR
40mg simvastatin dose. However only about 5-10% (can't remember the exact
figure) of patients got away with the 10% dose.
Pravastatin trials on the other hand all use fixed doses (40mg)
Chris
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