I'm also experiencing extremely long load times with the SPM GUI. It seems to be related to running the MacOS Accessibility Voice Control. I just switched it off and now operations run instantly.
With the Voice Control on, I can wait for 5 minutes for a simple GUI operation. It seems to be strongly related to browsing the hard disk. Everything else on my system more or less works fine--I did have some problems with MATLAB being a bit sluggish, but nothing compared to SPM's performance.
When I run a job, it runs no problem. The issue is with navigating around the GUI, and using the load file dialog box in particular. However i had the same sluggishness, waiting several minutes--when attempting to edit a weight vector in the fMRI Contrast Manager.
I tried clearing up hard disk space--I had only 2 GB free of 1000GB, but I now have 100GB free and it doesn't run any better. Only turning off the MacOS Accessibility Voice Control
I don't run either of the windowing apps suggested. System is MacOS Monterey v 12.4 on M1 Pro 16 GB, running MATLAB_R2022a, and SPM12: v7771 .
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