Lung Cancer Incidence, Survival and Treatment in Northern Ireland: a
retrospective.
by
Professor Gilbert MacKenzie
(formerly of UL, ROI and ENSAI, Fr.)
Abstract
This talk deals with the Northern Ireland Lung Cancer Study (NILCS),
the first population-based, multi-source, study of incidence (new
cases), conducted in 1991/92. At that time, Cancer Registration had not
been introduced and Northern Ireland relied on a Notification System
which was believed to be incomplete..
We report the basic results of the study and compare the incidence rate
in Northern Ireland with rates elsewhere in the British Isles in
1991/92, and subsequently, by considering the regional trends observed
over the last 30 years.
Incident cases in the NICLS study were followed-up for two years. The
effect of treatment on survival was evaluated using a MPR regression
model which is wholly parametric and has a non-proportional hazard
function. Adjusted treatment effects were computed and we discuss the
results of this analysis, recalling the observational nature of the
data. The findings are contrasted with the NICE Lung Cancer Guideline
(2010) and current survival data.
A treatment model for the NILCS was constructed in order to
determine: "who received curative treatment and why", and, whether
treatment allocation was consistent with the survival model? The
structure and performance of this logistic model was evaluated in terms
of months of life lost.
The findings highlight a number of different problem areas and the
need for futher research.
All welcome.
A link will follow in good time.
Gilbert MacKenzie
Meetings Secretary
RSSNI.
--
_____________________________
Prof. Gilbert MacKenzie,
Formerly of
Centre of Biostatistics,
Dept. of Mathematics & Statistics,
University of Limerick,
Limerick
Ireland
Email:[log in to unmask]
CBS ~http://ulsites.ul.ie/biostatistics
BIO-SI ~http://ulsites.ul.ie/biosi
Researchgate ~https://www.researchgate.net/profile/Gilbert_MacKenzie
Papers in pdf ~https://ulir.ul.ie/handle/10344/2626
Book: ~https://link.springer.com/book/10.1007%2F978-3-319-04579-5
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