Dear SPM Experts,
A while ago, I was attending a workshop and the speaker remarked that when performing FDRc correction in SPM, the correct interpretation of each cluster is that "there is at least one voxel within this cluster which is statistically significant". Therefore, there is no way to really know which brain regions (which the cluster covers) are activated per se. Does this sound right or did I misunderstand something?
Additionally, how does this interpretation differ when using FDRp or FWE method of multiple comparison correction? If I see a large cluster covering multiple brain regions, can I really not make any spatial localization inference?
Bonus: how should the results be reported? I see papers only list the peak coordinate and which brain region does the peak correspond to; tools like CAT12 (using spm_atlas), on the other hand, provide a detailed lookup about all the regions encompassed by the cluster and what percentage of the voxels in each cluster fall into which region. Are there any recommendations on what's the best way to report results?
Thank you for your time and help
Regards
PB
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