Dear SPM experts,
I aim at studying the longitudinal evolution of brain atrophy in AD patients.
I used the pairwise longitudinal registration of SPM12, and I was wondering which output to use in my statistical analyses in order to obtain the best index of atrophy progression.
Do I only have to use the dv images normalized to MNI space ? Or is it better to combine (multiply?) dv with the grey matter of avg ? Others propose to multiply the grey matter of avg by the Jacobian difference maps.
What are the differences between these approaches, and which one do you think is most appropriate ?
Thank you for your help.
Best,
Julien
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