Dear Kathleen,
On Thu, 31 Oct 2019 17:18:48 +0000, Hupfeld,Kathleen E <[log in to unmask]> wrote:
>Dear SPM experts,
>
>I'd like to use CAT12 to compare gray matter volumes and run brain/behavior correlations in a sample that includes ~30 young and ~30 older adults. I wanted to know if anyone had thoughts regarding the DARTEL warping used in CAT12 with aging subjects. Comparing the modulated, normalized T1s (wm*.nii) and the gray matter segments (mwp1*.nii) between subjects, the ventricles are still slightly larger in all of the OA subjects.
>
>E.g., below are screenshots of a young (left) and older (right) participant. Ventricles are larger on OA, so the crosshair is on the edge of gray matter for the young adult, but inside the ventricle for the old adult.
>Will this be generally problematic for my study?
Even of there remain some differences in the ventricles after spatial registration, the GM overlap looks fine except for the caudate nucleus. This might be only an issue if your hypothesis is linked to that region. However, you can also try the geodesic shooting registration (probably with 1mm voxel resolution) to see whether the overlap in these regions will improve.
>
>We have used ANTs (http://stnava.github.io/ANTs/) previously for normalizing T1s and fMRI images to MNI space in aging populations, which has performed very well for handling issues like large ventricles for old adults; however, given the large number of steps that run during CAT12's "segment" procedure, I'm not sure that ANTs could be interfaced well with CAT12?
It will be probably too complicated to use the ANT registration for CAT12...
Best,
Christian
>
>Any thoughts would be greatly appreciated.
>
>Best,
>Kathleen
>
>Modulated, normalized T1s:
>[cid:4cf6ab88-4dd3-4db5-aa40-eaefd693de8e]
>
>Gray matter segments for same two people, same coordinate:
>[cid:6e5e13e7-abd2-4825-931c-33b9f166c147]
>
>
>
>Kathleen Hupfeld
>
>PhD Candidate, Biobehavioral Science
>Neuromotor Behavior Lab
>Department of Applied Physiology & Kinesiology
>University of Florida
>
|