For that matter, the insulin *receptor* is a spectacular example of very
large conformational changes in a homodimer.
On 2019-10-09 15:27, Eleanor Dodson wrote:
> There are many insulin structures with domain shifts.
> 4ins and 1trz share sequence but have different conformations for one
> of the molecules..
> Eleanor Dodson
>
> On Wed, 9 Oct 2019 at 14:32, Tanner, John J. <[log in to unmask]>
> wrote:
>
>> The same enzyme adopting different quaternary structures is a form
>> of allosteric regulation. Jaffe's group has described this
>> phenomenon - the “morpheein" model of allosteric regulation.
>>
>> Reviews:
>> https://www.ncbi.nlm.nih.gov/pubmed/22182754 [2]
>> https://www.ncbi.nlm.nih.gov/pubmed/16023348 [3]
>>
>> John J. Tanner, PhD
>> Professor of Biochemistry and Chemistry
>> Associate Chair of Biochemistry
>> University of Missouri
>> 117 Schweitzer Hall
>> 503 S. College Avenue
>> Columbia, MO 65211
>> Phone: 573-884-1280
>> Email: [log in to unmask]
>> http://faculty.missouri.edu/~tannerjj/tannergroup/tanner.html [4]
>>
>>> On Oct 9, 2019, at 6:14 AM, Gabriela GARCIA RODRIGUEZ
>>> <[log in to unmask]> wrote:
>>>
>>> Dear CCP4BB subscribers,
>>>
>>> I am writing a discussion on extensive quaternary changes between
>>> two different homodimers of the same protein and I would like to
>>> ask you for any examples of your own work/that you know of to
>>> include in my analysis. Basically, any proteins known to exist in
>>> two different (or more) homodimerised states (suffering changes in
>>> domain organisation between states would be even more
>>> interesting).
>>> I would greatly appreciate any examples! Thank you for your time
>>> and attention.
>>>
>>> Warm regards,
>>>
>>> Gabriela
>>>
>>> ____
>>>
>>> GABRIELA GARCIA RODRIGUEZ
>>>
>>> [log in to unmask]
>>>
>>> PhD candidate
>>>
>>> Structural Biology Research Centre (SBRC)
>>>
>>> Vlaams Instituut voor Biotechnologie (VIB) - Vrije Universiteit
>>> Brussel (VUB)
>>>
>>> Pleinlaan 2- 1050 Brussels, Belgium
>>>
>>> -------------------------
>>>
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>>
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>
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> Links:
> ------
> [1] https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
> [2] https://www.ncbi.nlm.nih.gov/pubmed/22182754
> [3] https://www.ncbi.nlm.nih.gov/pubmed/16023348
> [4] http://faculty.missouri.edu/~tannerjj/tannergroup/tanner.html
> [5] https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
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