"Dear Sirs" - think again!
Anyhow, Alberto - this probably depends on how many images you have in
total and how many you have in different age groups. Two separate age
groups are unlikely to be sufficient. You may have to perform a linear
co-registration before non-linear co-registration as well, especially in
the case of movement/spontaneously altered head position (typical for
children).
Cheers,
Barbara
On 19/07/2019 12:49, Alberto Inuggi wrote:
> Dear Sirs
>
> I would need any suggestion to correctly perform a VBM analysis in a pediatric group.
> I have children ranging from 10 months up to 12 years. not so many children to create numerous subgroups.
>
> I could create a sort of study template through the following procedure:
>
> I select a reference subject REFSUBJ
> I non-linearly coregister each subject to REFSUBJ
> I create an average brain with all these refsubj-transformed images => MEAN_SUBJS
> I non-linearly coregister each subject (also REFSUBJ) to the latter mean image
> I create an average brain with all these refsubj-transformed images => my pediatric template in the REFSUBJ space
> I non-linearly register this template to the adult MNI_2mm.
>
> is this procedure able to manage such different brains? do you have any suggestions? like, e.g., divide my population in two age-groups since age differences are too big and cannot managed?
>
> thanks in advance
> regards,
>
> Alberto
>
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