Dear Sirs
I would need any suggestion to correctly perform a VBM analysis in a pediatric group.
I have children ranging from 10 months up to 12 years. not so many children to create numerous subgroups.
I could create a sort of study template through the following procedure:
I select a reference subject REFSUBJ
I non-linearly coregister each subject to REFSUBJ
I create an average brain with all these refsubj-transformed images => MEAN_SUBJS
I non-linearly coregister each subject (also REFSUBJ) to the latter mean image
I create an average brain with all these refsubj-transformed images => my pediatric template in the REFSUBJ space
I non-linearly register this template to the adult MNI_2mm.
is this procedure able to manage such different brains? do you have any suggestions? like, e.g., divide my population in two age-groups since age differences are too big and cannot managed?
thanks in advance
regards,
Alberto
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