Principal Computational Biologist, The Cancer Research UK Manchester Institute, Manchester, UK
Following the award of £4.9M by the Medical Research Council (MRC) to establish a Single Cell Research Centre (SCRC) at the University of Manchester, the CRUK Manchester Institute and Faculty of Life Sciences are together seeking a Principal Computational Biologist to join the SCRC. Based within the CRUK Manchester Institute, the post holder will focus on the analysis of genomics data derived from individual cancer cells, including Circulating Tumour Cells (CTCs) – see for example, Hodgkinson et al. (2014) Nature Medicine. You will join a highly collaborative team comprising the Clinical and Experimental Pharmacology (CEP) Group (led by Professor Caroline Dive CBE and Ged Brady) and the University of Manchester Computational and Evolutionary Biology Group (led by Magnus Rattray).
You will focus on establishing approaches for the integration and analysis of multiple genome-wide single-cell ‘-omics datasets including DNA and RNA sequencing, and on turning these into robust analytical pipelines that will be used to explore the clinical consequences of inter-cell heterogeneity. Longer-term ambitions include the analysis of single cell methylomics and ChIP sequencing data. You will have access to a dedicated HPC genomics facility based at the CRUK MI, and will write computationally intensive code to analyse high volumes of cancer genomics data.
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