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ALLSTAT  September 2018

ALLSTAT September 2018

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Subject:

JOB: Genome Analyst, AstraZeneca's 2 Million Genome Initiative, Cambridge, UK

From:

Petrovski, Slavé <[log in to unmask]>

Reply-To:

Petrovski, Slavé <[log in to unmask]>

Date:

Sat, 8 Sep 2018 10:47:27 +0000

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (75 lines)

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

AstraZeneca's Centre for Genomics Research (CGR) is looking for outstanding genome analysts to contribute to the genomic strategies of the CGR in an unprecedented genomic initiative, involving the analysis of up to 2 million genomes. This includes the sequencing of up to 500,000 participants from AstraZeneca and MedImmune clinical studies and analysing the sequence data from large population cohorts including the ~500,000 UK Biobank participants to identify genetic determinants for disease risk and patient stratification among core therapeutic areas of oncology, respiratory, cardiovascular and metabolic disease. Genomics will be fundamental to our laboratory research, our clinical trials and the launch of new precision medicines.

Opportunity:     Genome Analyst
Location:            Cambridge, UK
Salary:                Competitive & Excellent Benefits Package

Genome analysts will work with leaders in human genomics, designing and implementing novel approaches to analyse large-scale genomics data and to deliver innovative science to genome analytics, including structural variants and variants found among regions of the noncoding genome. Statistical genetic principled methodologies will be adopted to ensure that CGR is at the forefront of robust cohort-level analyses, to deliver novel insights into the biology of disease, the validation of new targets for medicines and the improvement of patient stratification opportunities.

Genome analysts will be part of a dynamic team in CGR's multidisciplinary genomics research environment comprising of bioinformaticians, computational biologists, genome scientists, software engineers, statistical geneticists, postdoctoral researchers, disease area specialists and clinician experts. You will also work closely with experts in translational science, drug discovery, pre-clinical modelling, and clinical development; thus, contributing to the broader objectives and success of the company-wide Genomics Initiative.

AstraZeneca is a science-led, global biopharmaceutical company, with a focused portfolio in core therapies. We are committed to improving the health and lives of people across the globe, through our broad research and development platform, and a growing late-stage pipeline. Working in over 100 countries, we have strength in emerging markets, and our medicines are used by millions of patients and clinicians worldwide.

Responsibilities:

  *   Coordinating and executing analyses within AstraZeneca's Centre for Genomics Research
  *   Applying innovative quantitative genomic analyses to large-scale cohort studies to identify clinically relevant disease and response loci
  *   Deliver novel insights into the biology of disease, validation of new targets for medicines and the improvement of selection of patients for clinical trials
  *   Intellectual involvement in the design and development of novel algorithms and tools to explore relationships between genetic variation and patient disease and treatment outcomes
  *   Supporting and refining the analysis framework and best practices for variant interpretation
  *   Assessing the scientific and technical integrity of algorithms and tools within the analysis pipeline
  *   Providing detailed reports regarding the study design, analysis approach and research findings
  *   Maintaining a well-developed knowledge of genomic science and technical advances in the international community
  *   Leading genomic science input into the drug development process
  *   Collaborating to apply genomic analysis with discovery and development teams
  *   Ensuring own work, and work of team, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other internal AstraZeneca standards and external regulations

Qualifications, Skills and Experience Required:
Essential:

  *   PhD degree (or equivalent experience) in Bioinformatics, Biostatistics, Complex Trait Genetics, Computational Biology, Statistical Genetics or a related discipline
  *   Experience in large-scale data analysis, applied statistics, and machine learning
  *   Ability to communicate effectively with team members and non-experts, both verbally and through documentation
  *   High level understanding or interest in the potential of genomics to impact drug discovery
  *   Ability to prioritize, problem-solve and perform difficult tasks while under pressure
  *   Ability to carry out duties under minimal supervision
  *   Excellent interpersonal skills and willingness to work within a team in a quickly evolving environment
  *   Track record of peer-reviewed publications in high-level scientific journals

Desirable:

  *   Previous experience in a similar role
  *   Experience in case-control sequencing based statistical analyses
  *   Experience quantifying and interpreting the clinical relevance of rare variants
  *   Familiarity with high performance and/or cloud computing
  *   Programming skills appropriate for large scale genomics analysis
  *   Familiarity working on genomics studies involving one of AstraZeneca's core therapeutic areas

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.


Contact:

VP & Head of Genome Analytics, Slavé Petrovski

E: [log in to unmask]<mailto:[log in to unmask]>



Applications close: September 17th, 2018
Find out more and apply here:
https://wd3.myworkday.com/astrazeneca/d/inst/15$392530/9925$69574.htmld
________________________________

AstraZeneca UK Limited is a company incorporated in England and Wales with registered number:03674842 and its registered office at 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0AA.

This e-mail and its attachments are intended for the above named recipient only and may contain confidential and privileged information. If they have come to you in error, you must not copy or show them to anyone; instead, please reply to this e-mail, highlighting the error to the sender and then immediately delete the message. For information about how AstraZeneca UK Limited and its affiliates may process information, personal data and monitor communications, please see our privacy notice at www.astrazeneca.com<https://www.astrazeneca.com>

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