Computational Biologist, The Cancer Research UK Manchester Institute
The overall goal of the Clinical and Experimental Pharmacology Group (CEP) in the CRUK Manchester Institute led by Professor Caroline Dive CBE, is to develop, validate, and implement biomarkers that facilitate the optimisation of cancer patient treatment – personalised medicine. In this regard, CEP is an acknowledged world leader in the study of minimally invasive biomarkers (liquid biopsies) suitable for patient monitoring. Our biomarker research integrates clinical, molecular and computational science into a highly interdisciplinary programme; advanced computational biology is critical to the biomarker agenda.
An exciting opportunity now presents for a Computational Biologist to join CEP, positioned within the newly established Manchester Centre for Cancer Biomarker Sciences (MCCBS) Bioinformatics and Biostatistics team (BBS). You will work alongside a multidisciplinary team of clinicians, biologists, chemists and computational scientists to analyse genomics data arising from patient tumours. These will include deep sequencing data arising from Circulating Tumour Cells (CTCs) and circulating tumour DNA (ctDNA), as well as proteomics, sequencing and functional genomics data arising from preclinical models. A major focus will be the establishment of novel computational strategies that integrate these different ‘omics datasets in order to advance our understanding of understand tumour heterogeneity.
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