Hi John,
We did some extensive work on this with Siemens and do see a slight negative bias at the low end compared to our Tosoh G8s. This is nowhere near as bad as you are seeing.
We ran some IFCC calibrators (31, 44, 59, 68 and 90 mmol/mol) through 3 different DCA Vantage devices and the results were spot on.
I am more concerned about the high bias we continue to see above 100 mmol/mol on the DCA which my clinicians tell me influences their clinical practice.
I have reported this to the MHRA.
Dr Kerry Whiting
POCT Specialty Lead, Berkshire & Surrey Pathology Services
________________________________________
From: ACB Point-of-Care Testing <[log in to unmask]> on behalf of Shepherd, John <[log in to unmask]>
Sent: 03 May 2018 16:27
To: [log in to unmask]
Subject: Re: [[SPAM]] - ACB-POCT Digest - 20 Feb 2018 to 22 Feb 2018 - Special issue (#2018-26)
Dear DCA users.
Before I ask the MHRA to intervene, can anyone show recent acceptable comparability between their Lab Method and Siemens DCA 2000 HbA1c using patient samples.
Siemens make no claim as to comparability with any other method. We see a 15 to 20 % neg bias at the target threshold levels vs Lab, so either the DCA or the Lab (Menarini) is wrong.
EQA (as previously stated) doesn’t reveal the difference.
Kind Regards
John
Mr John Shepherd FRCPath | Consultant in Clinical Biochemistry
Blood Sciences, Pathology Dept, Hull and East Yorkshire Hospitals, Anlaby Road, HULL, HU13 2JZ
B 00 44 (0)1482 607707 (direct)
-----Original Message-----
From: ACB Point-of-Care Testing [mailto:[log in to unmask]] On Behalf Of ACB-POCT automatic digest system
Sent: 22 February 2018 11:26
To: [log in to unmask]
Subject: [[SPAM]] - ACB-POCT Digest - 20 Feb 2018 to 22 Feb 2018 - Special issue (#2018-26)
There are 2 messages totaling 10420 lines in this issue.
Topics in this special issue:
1. DCA 2000 HbA1c
2. POCT and Pathology Events
----------------------------------------------------------------------
Date: Thu, 22 Feb 2018 08:40:38 +0000
From: "BAULCH, David (FRIMLEY HEALTH NHS FOUNDATION TRUST)"
<[log in to unmask]>
Subject: Re: DCA 2000 HbA1c
Hi John,
Would it possible to swap the data you have on this?
My email is [log in to unmask]<mailto:[log in to unmask]>
Cheers,
Dave
From: ACB Point-of-Care Testing [mailto:[log in to unmask]] On Behalf Of BAULCH, David (FRIMLEY HEALTH NHS FOUNDATION TRUST)
Sent: 16 February 2018 16:38
To: [log in to unmask]
Subject: Re: DCA 2000 HbA1c
We're also seeing this with a routine lot verification, quite a significant negative bias (roughly 10%).
Not sure what the matrix of NEQAS samples are but a positive bias was picked up by Qpoint EQAS too - the matrix here is fresh whole blood.
We will attempt to re-verify the lot (Mon or Tues) but it can't be a coincidence others have picked this up too.
Dave
From: ACB Point-of-Care Testing [mailto:[log in to unmask]] On Behalf Of Shepherd, John
Sent: 16 February 2018 16:26
To: [log in to unmask]<mailto:[log in to unmask]>
Subject: DCA 2000 HbA1c
Historically our DCA results are negatively biased when comparing patients with Lab (Menarini). EQA however shows a slight pos bias(NEQAS) Siemens have recalibrated the DCA due to the pos EQA bias and there is now an unacceptable negative bias with patients(Minus 6-8 mmol/mol) - Has anyone else seen this?
Looks like the EQA matrix isn't behaving like patient blood!
Has anyone else re-evaluated following the notice from Siemens?
Many Thanks
John
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Date: Thu, 22 Feb 2018 11:15:18 +0000
From: Nichola Cadwallader <[log in to unmask]>
Subject: POCT and Pathology Events
Hello,
There are a few events that might be of interest to some of you in the market at the moment:
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I’ve attached the brochures for your use and you can contact me directly at [log in to unmask]<mailto:[log in to unmask]> if you would like to make an enquiry / booking or reservation.
All the best,
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[SBK Logo 2014]Nichola Cadwallader
Marketing Associate
Follow on Twitter<https://twitter.com/NicholacSBK> | Connect on LinkedIn<https://uk.linkedin.com/in/nichola-cadwallader-b2126268>
Email: [log in to unmask]<mailto:[log in to unmask]>
Telephone: 01732 897788
Address: 10 Churchill Square, Kings Hill, West Malling, Kent ME19 4YU View our forthcoming events:
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SBK (UK) Ltd is registered in England and Wales, company number 5436886 and registered address Henwood House, Henwood, Ashford, Kent TN24 8DH
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End of ACB-POCT Digest - 20 Feb 2018 to 22 Feb 2018 - Special issue (#2018-26)
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