PSI Training Course: Multiple Testing in Confirmatory Clinical Trials
- *Date:* 09 May, 2018
- *Address:* Crowne Plaza, London Heathrow
*To be presented by* *Carl-Fredrik Burman & Lisa Hampson*
Regulatory agencies require strong control of the Type I Error for all
confirmatory statistical tests. Multiplicity issues can arise for several
reasons, e.g.: the possibility of winning on two different endpoints (like
PFS and OS), interim analyses, or testing for effects in several patient
groups. This course will focus on the principles underlying multiple
comparison procedures and their applications to confirmatory clinical
trials. We will describe simple ways to construct valid multiple tests, and
will explore how tests can be incorporated into recycling strategies.
Group-sequential and some common adaptive tests will also be described.
Concepts will be introduced through a combination of lectures, exercises,
and discussion sessions where groups will focus on the issues that might be
encountered when designing and communicating statistical tests.
The following topics will be covered:
- Introduction to Multiple Testing
- Recycling and graphical methods
- Group sequential and adaptive designs
- Operating characteristics and improving them using correlations
- Using decision analysis to optimise multiple testing procedures
Register here:
https://www.psiweb.org/events/event-item/2018/05/09/default-
calendar/psi-training-course-multiple-testing-in-
confirmatory-clinical-trials
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